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Published articles on Synergo bladder cancer

& ARTICLES 1991-2021

Brummelhuis ISG, Wimper Y, Witjes-van Os HGJM, Arends TJH, van der Heijden AG, Witjes JA. Long-Term Experience with Radiofrequency-Induced Hyperthermia Combined with Intravesical Chemotherapy for Non-Muscle Invasive Bladder Cancer. Cancers (Basel). 2021 Jan 20;13(3):377. Full article available on MDPI. View Abstract.

J. Alfred Witjes Radiofrequency-induced Thermochemotherapy for Recurrent Non–muscle-invasive Bladder Cancer: A New Treatment for an Unmet Need? Eur Urol. 2019 Jan;75(1):72-73 

Comment on Radiofrequency-induced Thermo-chemotherapy Effect Versus a Second Course of Bacillus Calmette-Guérin or Institutional Standard in Patients with Recurrence of Non-muscle-invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guérin Therapy (HYMN): A Phase III, Open-label, Randomised Controlled Trial. [Eur Urol. 2019]

Wei Shen Tan et al. Radiofrequency-induced Thermo-chemotherapy Effect Versus a Second Course of Bacillus Calmette-Guérin or Institutional Standard in Patients with Recurrence of Non–muscle-invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guérin Therapy (HYMN): A Phase III, Open-label, Randomised Controlled Trial Eur Urol. 75 2019 63– 71

van Valenberg FJPKajtazovic ACanepa GLüdecke GKilb JIAben KKHNativ OMadaan SAyres BIssa RWitjes JA.

Intravesical Radiofrequency-Induced Chemohyperthermia for Carcinoma in Situ of the Urinary Bladder: A Retrospective Multicentre Study.

Bladder Cancer. 2018 Oct 29;4(4):365-376. doi: 10.3233/BLC-180187.

Benjamin Ayres, Chris Backhouse, Domagoj Tomic, Babbin John, Matthew Perry, Mike Bailey, Rami Issa, London, United Kingdom

10-year experience of RITE thermochemotherapy for High Risk Non Muscle Invasive Bladder Cancer that has failed BCG

J Urology April 2018 Volume 199, Issue 4, Supplement, Page e96 View abstract presentation

Kilb, J.-I., Hauptmann, A., Wagenlehner, F. & Luedecke, G . (2018)

Long-term results of organ preservation rate and progression risk in high-risk non-muscleinvasive bladder cancer (NMIBC) patients treated with radiofrequency-induced thermochemotherapy effect (RITE) with the Synergo system.

Journal of Clinical Oncology 36, 456-456, doi:10.1200/JCO.2018.36.6_suppl.456 (2018). View abstract presentation

van Valenberg, F. J. P. et al. (2017)

Intravesical radiofrequency induced hyperthermia enhances mitomycin C accumulation in tumour tissue.

Int J Hyperthermia, 1-6, doi:10.1080/02656736.2017.1406618 (2017).

Benacka, M., Benamran, D. A., Wirth, G. & Iselin, C. E. (2017)

Intravesical microwave thermo-chemotherapy for the treatment of non-invasive bladder cancer.

Rev Med Suisse 13, 2087-2091 (2017).

Pierconti, F. et al. (2017)

Cytological and histological changes in the urothelium produced by electromotive drug administration (EMDA) and by the combination of intravescical hyperthermia and chemotherapy (thermochemotherapy).

Pathology - Research and Practice 213, 1078-1081, doi: prp.2017.07.026 (2017).

Campodonico, F. et al. (2017)

Intravesical Chemotherapy and Chemohyperthermia in Non-Muscle-Invasive Bladder Cancer; An Overview on Drug Administration Technologies and Pharmacokinetics.

Curr Drug Metab 18, 657-665, doi:10.2174/1389200218666170427092421 (2017).

Ayres B. et al. (2017)

5-year outcomes of RITE thermochemotherapy for BCG unresponsive high risk non muscle invasive bladder cancer 

EAU 2017, Moderated Poster, London

Colombo, R., van Valenberg, H., Moschini, M. & Witjes, J. A. (2016)

Radiofrequency-induced thermo-chemotherapy effect (RITE) for non muscle invasive bladder cancer treatment: current role and perspectives.

Urologia 83, 7-17, doi:10.5301/uro.5000197 (2016).

Tom J.H. Arends, Ofer Nativ, Massimo Maffezzini, Ottavio de Cobelli, Giorgio Canepa, Fabrizio Verweij,

Boaz Moskovitz, Antoine G. van der Heijden, J. Alfred Witjes

Results of a Randomised Controlled Trial Comparing Intravesical Chemohyperthermia with Mitomycin C Versus Bacillus
Calmette-Gue´rin for Adjuvant Treatment of Patients with Intermediate- and High-risk Non–Muscle-invasive Bladder Cancer

European Urology, Volume 69 Issue 6, June 2016, Pages 1046-1052 VIEW >>



Prasanna Sooriakumaran, Virginia Chiocchia, Susan Dutton, Aakash Pai, Benjamin E. Ayres, Pieter Le Roux, Michael Swinn, 

Michael Bailey, Matthew J.A. Perry, Rami Issa

Predictive Factors for Time to Progression after Hyperthermic Mitomycin C Treatment for High-Risk Non-Muscle Invasive Urothelial Carcinoma of the Bladder: An Observational Cohort Study of 97 Patients

Urol Int 2016;96:83-90 VIEW >>



Sakıp Erturhan, Haluk Sen, Asaf Demirbag, Omer Bayrak, Faruk Yagcı, lker Seckiner and Ahmet Erbagcı.

Thermo-Chemotherapy in adjuvant treatment of primary high risk non muscle invasive bladder cancers: single center results

Arch. Esp. Urol. 2015; 68 (8): 666-671 VIEW >>


Lüdecke G, Schäfer L, Nativ O, Witzsch U, Hanitzsch H, Hasner F, Issa R, Witjes F, Weidner W

Radiofrequence induced hyperthermia chemotherapy (RIHTC) in high-risk non-muscle invasive bladder cancer (NMIBC):

Multiinstitutional, international outcome analysis of 271 treated patients with a follow-up time of more than 2 years

EAU, 2015, Moderated Poster, Madrid VIEW >>



Tom J. H. Arends, Johannes Falke, Rianne J. M. Lammers, Diederik M. Somford, Jan C. M. Hendriks, Mirjam C. A. de Weijert,

Harm C. Arentsen, Antoine G. van der Heijden, Egbert Oosterwijk, J. Alfred Witjes

Urinary cytokines in patients treated with intravesical mitomycin-C with and without hyperthermia

World J Urol. 2014 Dec DOI 10.1007/s00345-014-1458-3 VIEW >>

Arends TJ, van der Heijden AG, Witjes JA

Combined Chemohyperthermia: The 10-Years Monocentric Experience in 160 Non-Muscle Invasive Bladder Cancer Patients

J Urol. 2014 Apr 1. pii: S0022-5347(14)03189-9. doi: 10.1016/j.juro.2014.03.101. [Epub ahead of print] VIEW >>



Massimo Maffezzini · Fabio Campodonico · Giorgio Canepa ·Egi Edward Manuputty · Stefania Tamagno · Matteo Puntoni

Intravesical mitomycin C combined with local microwavehyperthermia in non‑muscle‑invasive bladder cancer with increased European Organization for Research and Treatment of Cancer (EORTC) score risk of recurrence and progression

Cancer Chemother Pharmacol Published online March 2014 VIEW >>



R. Colombo, M. Moschini

Role of the combined regimen with local chemotherapy and Mw-induced hyperthermia for non-muscle invasive bladder cancer management. A systematic review

Urologia 2013 (80) 2: 112-119 VIEW >>



Lüdecke G, Schäfer L, Weidner W, Schmidt M, Hanitzsch H, Hasner F

Radiofrequency hyperthermia chemotherapy ( HTC ) in high- and extreme high-risk non-muscle-invasive bladder cancer

(NMIBC) performed by the German HTC study group: Impressive high chance of organ preservation documented in

a cohort study with long-time follow-up 

Journal of Urology, The Vol. 189, Issue 4, Supplement, p700 2013 



G. Luedecke, F. Hasner, H. Hanitzsch, M. Schmidt

The German study group of intravesical-hyperthermia chemotherapy in non-muscle invasive bladder cancer presents their

long-term results in efficacy and tolerability for optimized adjuvant therapy and bladder preservation

ASCO 2013, 2013 Genitourinary Cancers Symposium 



A. Volpe M. Racioppi L. Bongiovanni D. D’Agostino A. Totaro A. D’Addessi F. Marangi G. Palermo F. Pinto E. Sacco P.F. Bassi  ​Thermochemotherapy for Non-Muscle-Invasive Bladder Cancer: Is There a Chance to Avoid Early Cystectomy?

Urologia Internationalis September 2012 VIEW >> 



​Boaz Moskovitz, Sarel Halachmi, Michal Moskovitz, Omri Nativ, Ofer Nativ

10‑year single-center experience of combined intravesical chemohyperthermia for nonmuscle invasive bladder cancer

Future Oncol. August 2012 VIEW >>


Rianne J.M. Lammers, J. Alfred Witjes, Brant A. Inman, Ilan Leibovitch, Menachem Laufer, Ofer Nativ, Renzo Colombo

The Role of a Combined Regimen With Intravesical Chemotherapy and Hyperthermia in the Management of Non-muscle-invasive Bladder Cancer: A Systematic Review  

European Urology, Volume 60 Issue 1, July 2011, Pages 81-93 VIEW >>

Renzo Colombo, Andrea Salonia, Zvi Leib, Michele Pavone – Macaluso, and Dov Engelstein

Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). 

BJU International, 10/05/2010 VIEW >> 



Ofer Nativ, J. Alfred Witjes, Kees Hendricksen, Michael Cohen, Daniel Kedar, Ami Sidi, Renzo Colombo and Ilan Leibovitch.
Combined Thermo-Chemotherapy for Recurrent Bladder Cancer After Bacillus Calmette-Guerin.

J Urology October 2009 VIEW >>



Halachmi S, Moskovitz B, Maffezzini M, Conti G, Verweij F, Kedar D, Sandri SD, Nativ O, Colombo R.
Intravesical mitomycin C combined with hyperthermia for patients with T1G3 transitional cell carcinoma of the bladder.

Urol Oncol. 2009 Apr 21. V VIEW >>



J. A. Witjes, K. Hendricksen, O. Gofrit, O. Risi, O. Nativ
Intravesical hyperthermia and Mitomycin-C for (BCG refractory) Carcinoma in Situ of the urinary bladder.

World J Urol (2009) VIEW>>



Antoine G. van der Heijden, Christina A. Hulsbergen Van de Kaa, J. Alfred Witjes.
The Influence of Thermo-Chemotherapy on Bladder Tumours: An Immunohistochemical Analysis. 

World J Urol (2007) 25:303-308 VIEW >>



Moskovitz B, Meyer G, Kravtzov A, Gross M, Kastin A, Biton K, Nativ O.
Thermo-Chemotherapy for intermediate or high-risk recurrent superficial bladder cancer patients.

Ann Oncol.2005 Apr,16(40:585-9) VIEW >>



Van der Heijden A.G, Verhaegh G, Cornelius F. J. J, Schalken J.A, Witjes J.A.
Effect of Hyperthermia on the Cytotoxicity of Four Chemotherapeutic Agents Currently Used for the Treatment of

Transitional Cell Carcinoma of the Bladder - An in Vitro Study. J Urol Vol. 173, 1375-1380, 2005 VIEW >>


Van der Heijden A.G, Cornelius F. J. J, Verhaegh G, O'Donnell M.A, Schalken J.A, Witjes J.A.
The Effect of Hyperthermia on Mitomycin-C Induced Cytotoxicity in Four Human Bladder Cancer Cell Lines.

Eur Urol. 2004 Nov;46(5):670-674 VIEW >>



Van der Heijden A.G, Kiemeney L.A, Gofrit O.N, Nativ O, Sidi A, Leib Z, Colombo R, Naspro R,

Pavone M, Baniel J, Hasner F, Witjes J.A.
Preliminary European Results of Local Microwave Hyperthermia and Chemotherapy Treatment in

Intermediate or High Risk Superficial Transitional Cell Carcinoma of the Bladder.

Eur Urol 46:65-72;2004 VIEW >>



Gofrit O.N, Shapiro A, Pode D, Sidi A, Nativ O, Leib Z, Witjes J.A, Van Der Heijden A.G, Naspro R, Colombo R.
Combined Local Bladder Hyperthermia and Intravesical Chemotherapy for the Treatment of High Grade

Superficial Bladder Cancer.

Urol 63(3):466-471;2004 VIEW >>



Colombo R, Da Pozzo L.F, Salonia A, Rigatti P, Leib Z, Baniel J, Caldarera E, Pavone-Macaluso M.
Multicentric Study Comparing Intravesical Chemotherapy Alone and With Local Microwave Hyperthermia for

Prophylaxis of Recurrence of Superficial Transitional Cell Carcinom
J Clin Oncol. 2003 VIEW >>



Wolfson L.R, Moskovitz B, Dekel Y, Kugel V, Koren R.
Combined intravesical hyperthermia and mitomycin chemotherapy: a preliminary in-vivo study.
Int J Exp Path. 84:145-152;2003 VIEW >>



Colombo R, Salonia A, Da Pozzo L.F, Naspro R, Freschi M, Paroni R, Pavone-Macaluso M, Rigatti P.
Combination of intravesical chemotherapy and hyperthermia for the treatment of superficial bladder cancer:

preliminary clinical experience.
Crit Rev Oncol Hematol. 47(2):127-39;2003 VIEW >>



Van Der Heijden A.G, Witjes J.A.
Future strategies in the diagnosis, staging and treatment of bladder cancer.
Curr Opin Urol 13(5):389-95;2003



Van Der Heijden A.G, Witjes J.A.
Intervesical Chemotherapy: An Update - New Trends and Perspectives.
EAU Update Series 1:71-79;2003


Paroni R, Salonia A, Lev A, Da Pozzo L.F, Cighetti G, Montorsi F, Rigatti P, Colombo R.
Effect of local hyperthermia of the bladder on mitomycin C pharmacokinetics during intravesical chemotherapy

for the treatment of superficial transitional cell carcinoma.

Br J Clin Pharmacol 52:273-278;2001 VIEW >>


Colombo R, Brausi M, Da Pozzo L.F, Salonia A, Montorsi F, Scattoni V, Roscigno M, Rigatti P.
Thermo-chemotherapy and electromotive drug administration of mitomycin C in superficial bladder cancer eradication.

Eur Urol 39:95-100;2001 


Rigatti P, Lev A, Da Pozzo L.F, Salonia A, Colombo R.
Locally induced hyperthermia in bladder cancer. Bladder Cancer: Biology, Diagnosis and Management,

Chapter 22, Oxford Medical Publication, Ed. K.N. Syrigos & D.G. Skinner, 1999 


Colombo R, Da Pozzo L.F, Lev A, Salonia A, Rigatti P, Leib Z, Servadio C, Caldarera E, Pavone-Macaluso M.
Local microwave hyperthermia and intravesical chemotherapy as bladder sparing treatment for select multifocal

and unresectable superficial bladder tumors.

J Urol 159:783-787;1998 VIEW >>



Paroni R, Arcelloni C, De Vecchi E, Fermo I, Mauri D, Colombo R.
Plasma mitomycin C concentrations determined by HPLC coupled to solid-phase extraction.
Clin Chem 43:615-618;1997 VIEW >>



Colombo R, Da Pozzo L.F, Lev A, Freschi M, Gallus G, Rigatti P.
Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus

chemotherapy alone for superficial bladder cancer.

J Urol 155:1227-1232;1996 VIEW >>



Colombo R, Lev A, Da Pozzo L.F, Freschi M, Gallus G, Rigatti P.
A new approach using local combined microwave hyperthermia and chemotherapy in superficial

transitional bladder carcinoma treatment.

J Urol 153:959-963;1995 VIEW >>


Rigatti R, Lev A, Colombo R.
Combined intravesical chemotherapy with mitomycin C and local bladder microwave-induced hyperthermia

as a preoperative therapy for superficial bladder tumors - A preliminary clinical study.

Eur Urol 20:204-210;1991 VIEW >>

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